Definition of Zonisamide

A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hyper-synchronization. Although zonisamide shows affinity for the gamma-aminobutyric acid (GABA)/benzodiazepine receptor ionophore complex, it does not potentiate the synaptic activity of GABA. In addition, this agent also facilitates both dopaminergic and serotonergic neurotransmission.

Zonisamide is from the group

Anticonvulsant Agent

Other Names for Zonisamide

Zonisamide
1,2-Benzisoxazole-3-methanesulfonamide
Excegram
ZONISAMIDE
Zonegran

Source

NCI Thesaurus License

Topics #2-Benzisoxazole-3-methanesulfonamide Excegram ZONISAMIDE Zonegran #Zonisamide 1