Definition of Zoledronate

A synthetic imidazole bisphosphonate with anti-bone-resorption activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small gtpase signalling proteins, which are important in the process of osteoclast turnover. Decreased bone turnover and stabilization of the bone matrix contribute to the analgesic effect of zoledronic acid with respect to painful osteoblastic lesions. The agent also reduces serum calcium concentrations associated with hypercalcemia.

Zoledronate is from the group

Biphosphonate
Bone Resorption Inhibitor
Malignancy-Associated Hypercalcemia Inhibitor

Other Names for Zoledronate

Zoledronic Acid
CGP 42446
CGP42446A
NDC-Zoledronate
Reclast
ZOL 446
ZOLEDRONIC ACID
Zometa
[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid

Source

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Topics #Zoledronic Acid CGP 42446 CGP42446A NDC-Zoledronate Reclast ZOL 446 ZOLEDRONIC ACID Zometa [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid