Definition of Zinc Finger Protein-147

Encoded by human ZNF147 Gene (TRIM Family, RING finger Family), the ubiquitous 630-amino acid 71 kD cytoplasmic estrogen-responsive Zinc finger protein 147 has potential DNA-binding and dimerization-transactivation domains, which suggest that ZNF147 may act as a transcription factor similar to other trim family members. The trim motif includes three zinc-binding domains, a SPRY domain, a RING, a B-Box Type 1 and Type 2, and a coiled-coil region. Zinc finger protein 147 is a RING-finger-dependent ubiquitin ligase (E3) that targets proteolysis of 14-3-3-sigma, a negative cell cycle regulator that causes G2 arrest. Lack of EFP function results in 14-3-3-sigma accumulation — 14-3-3-sigma is a target for proteolysis by EFP, leading to cell proliferation. (from Swiss-Prot, LocusLink, OMIM, and NCI)

Zinc Finger Protein-147 is from the group

E3 Ubiquitin Ligase

Other Names for Zinc Finger Protein-147

Zinc Finger Protein 147
EFP
Estrogen-Responsive Finger Protein
TRIM25
Tripartite Motif Protein TRIM25
Tripartite Motif-Containing 25
Z147
ZNF147
Zinc Finger Protein-147

Source

NCI Thesaurus License

Topics #Zinc Finger Protein 147 EFP Estrogen-Responsive Finger Protein TRIM25 Tripartite Motif Protein TRIM25 Tripartite Motif-Containing 25 Z147 ZNF147 Zinc Finger Protein-147