Definition of Zinc Finger Protein-145

Expressed in early myeloid cells, peripheral mononuclear cells, and in ovary, kidney, and lung by retinoic acid induced human ZNF145 Gene (Krueppel Family), alternative isoforms PLZFA (550-aa) and PLZFB (673-aa, 74-kDa) of nuclear Zinc finger protein 145 are probable transcription factors containing a BTB/POZ domain. Conserved N-terminal protein interaction BTB/POZ domains of some C2H2 transcription factors interact with components of histone deacetylase complex and repress transcription. ZNF145 may play a role in myeloid maturation and development, or maintenance of differentiated tissues. A growth-inhibitory and pro-apoptotic factor in limb bud formation, ZNF145 is an axial and appendicular skeletal anterior/posterior patterning mediator that regulates HOX gene expression. APL associated translocation t(11 — 17)(q32 — q21) involves ZNF145 and RARA. (NCI)

Zinc Finger Protein-145 is from the group

Transcription Repressor Corepressor

Other Names for Zinc Finger Protein-145

Zinc Finger Protein 145
PLZF
Promyelocytic Leukemia Zinc Finger Protein

Source

NCI Thesaurus License

Topics #Zinc Finger Protein 145 PLZF Promyelocytic Leukemia Zinc Finger Protein