Definition of Zebularine

A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits dna methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions.

Zebularine is from the group

DNA Methyltransferase Inhibitor

Other Names for Zebularine

Zebularine
1-beta-D-Ribofuranosyl-2(1H)-pyrimidinone
2-Pyrimidone-1-beta-D-riboside
Pyrimidin-2-one beta-Ribofuranoside

Source

NCI Thesaurus License

Topics #Zebularine 1-beta-D-Ribofuranosyl-2(1H)-pyrimidinone 2-Pyrimidone-1-beta-D-riboside Pyrimidin-2-one beta-Ribofuranoside