Definition of ZD9331

An orally available non-polyglutamatable quinazoline derivative with potential antineoplastic activity. Plevitrexed, behaves as a folate analogue, is transported into the cell via alpha isoform of the folate receptor (alpha-FR) and, to a lesser extent, by reduced folate carrier (RFC). Intracellularly, this agent selectively binds to the folate binding site of thymidylate synthase, thereby hampering thymidine synthesis that leads to dna synthesis inhibition and subsequently inducing apoptosis. RFC is ubiquitously expressed in normal tissue, alpha-FR, however, is overexpressed in a variety of tumors while its expression in normal tissue is very low.

ZD9331 is from the group

Folate Antagonist
Thymidylate Synthase Inhibitor

Other Names for ZD9331

Plevitrexed
(alphaS)-alpha-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid
BCG 9331
Vamidex
Vamydex
ZD9331

Source

NCI Thesaurus License

Topics #4-Dihydro-2 #7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid BCG 9331 Vamidex Vamydex ZD9331 #Plevitrexed (alphaS)-alpha-[[4-[[(1