Definition of ZD-6474

An orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.

ZD-6474 is from the group

Tyrosine Kinase Inhibitor

Other Names for ZD-6474

Vandetanib
AZD6474
ZD-6474
ZD6474
Zactima

Source

NCI Thesaurus License

Topics #Vandetanib AZD6474 ZD-6474 ZD6474 Zactima