Definition of Yttrium Y 90 SMT 487

A radiotherapeutic containing an octreotide derivative, edotreotide, labeled with yttrium 90 (Y-90) with potential antineoplastic activity. yttrium Y-90 edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of octreotide and chelated via dodecanetetraacetic acid (DOTA) to Y-90. Like the somatostatin analogue octreotide, this radioconjugate binds to somatostatin receptors (SSTRs), especially type 2, present on the cell membrane of many types of neuroendocrine tumors, thereby delivering beta emitting nuclide Y-90 to SSTR-positive cells resulting in tissue specific cytotoxicity.

Yttrium Y 90 SMT 487 is from the group

Radioimmunoconjugate

Other Names for Yttrium Y 90 SMT 487

Yttrium Y 90-Edotreotide
Y-90 OctreoTher
Yttrium Y 90 -DOTATOC
Yttrium Y 90 SMT 487
Yttrium Y 90-DOTA-Tyr3-Octreotide
Yttrium Y 90 SMT 487
Yttrium Y 90-DOTA-tyr3-octreotide

Source

NCI Thesaurus License

Topics #Yttrium Y 90-Edotreotide Y-90 OctreoTher Yttrium Y 90 -DOTATOC Yttrium Y 90 SMT 487 Yttrium Y 90-DOTA-Tyr3-Octreotide Yttrium Y 90 SMT 487 Yttrium Y 90-DOTA-tyr3-octreotide