Definition of XRP9881

A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic properties. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.

XRP9881 is from the group

Taxane-Site Binding Agent
Taxane Compound

Other Names for XRP9881

Larotaxel
RPR 109881A
RPR-109881
Taxoid-109881

Source

NCI Thesaurus License

Topics #Larotaxel RPR 109881A RPR-109881 Taxoid-109881