Definition of XL647

An orally active receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. XL647 binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR — ERBB1), epidermal growth factor receptor 2 (HER2 — ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). This results in the inhibition of tumor growth and angiogenesis, and eventually leads to tumor regression.

XL647 is from the group

Tyrosine Kinase Inhibitor

Other Names for XL647

XL647

Source

NCI Thesaurus License

Topics #XL647