Definition of XIAP-Associated Factor-1

Widely expressed (highest in heart, ovary — lowest in brain, testis) by human XAF1 Gene (IAP Family), 317-aa 37-kDa XIAP-Associated Factor 1 contains 3 Cys-rich BIR domains (bind to and inhibit caspases), 7 zinc fingers, and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. Associated with nuclear redistribution of XIAP, cytoplasmic XAF1 appears to antagonize nuclear XIAP inhibition of CASP3 activity. (NCI)

XIAP-Associated Factor-1 is from the group

Apoptosis Promoter

Other Names for XIAP-Associated Factor-1

XIAP-Associated Factor 1
XAF1
ZAP-1

Source

NCI Thesaurus License

Topics #XIAP-Associated Factor 1 XAF1 ZAP-1