Definition of WRN Protein

The WS gene encodes WRN, a 1,432-amino acid polypeptide. WRN is a member of the RecQ family of DNA helicases that unwind duplex DNA. It can also digest DNA exonucleolytically with 3′-5′ polarity. WRN may facilitate pol d-mediated dna replication and/or dna repair and disruption of WRN-DNA polymerase delta interaction in WS cells may contribute to the S-phase defects and/or the unusual sensitivity to a limited number of DNA damaging agents. (Proc Natl Acad Sci U S A 2000 Apr 25 — 97(9):4603-8)

WRN Protein is from the group

RecQ Helicase Family Protein

Other Names for WRN Protein

WRN Protein
WRN
Werner Syndrome Protein

Source

NCI Thesaurus License

Topics #WRN Protein WRN Werner Syndrome Protein