CHICAGO—Women who do not take hormone therapy after menopause may have an increased risk for breast cancer if they have gained weight throughout adulthood rather than maintaining a stable weight, according to a report in the October 22 issue of Archives of internal medicine, one of the JAMA/Archives journals.

Obesity is known to be a risk factor for developing breast cancer after menopause, according to background information in the article. Estrogens may accumulate in fat tissue, potentially initiating or promoting the growth of cancerous cells in the breast.

Jiyoung Ahn, Ph.D., of the National Cancer Institute , Bethesda, Md., and colleagues analyzed data from 99,039 postmenopausal women who were part of the National Institutes of Health–AARP diet and Health Study. In 1996, the women reported their current body measurement s and weight, plus their weight at ages 18, 35 and 50. body mass index (BMI) was used to classify the women as underweight, normal weight, overweight or obese.

Through 2000, 2,111 of the women developed breast cancer. In women who did not take hormone therapy, gaining weight in the early reproductive years (age 18 to 35), late reproductive years (age 35 to 50), perimenopausal and postmenopausal years (age 50 to the current age) and throughout adulthood (age 18 to the current age) were each associated with an increased risk of developing breast cancer compared with maintaining a stable weight during those periods.

Women who were not obese or overweight at age 18 but were at ages 35 and 50 had 1.4 times the risk of developing breast cancer compared with women who maintained a normal weight, while those who were overweight or obese at ages 18, 35 and 50 had no increased risk. Women who lost weight had the same breast cancer risk as those whose weight remained stable.

“Because weight gain during adulthood mainly reflects the deposition of fat mass rather than lean body mass, weight gain potentially represents age-related metabolic change that may be important in breast cancer development ,” the authors write. “These findings may reinforce public health recommendations for the maintenance of a healthy weight throughout adulthood as a means of breast cancer prevention .”
(Arch Intern Med. 2007;167(19)2091-2102.

Editor's Note: This research was supported by the intramural research program of the National Institutes of Health, National Cancer Institute. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

For more information, contact JAMA/Archives media relations at 312/464-JAMA (5262) or e-mail mediarelations{at}jama-archives.org .

Topics #Breast Cancer Risk #menopause #Weight Gain