U.S. Marshals, at the request of the Food and Drug Administration, today seized drug products manufactured by Caraco Pharmaceutical Laboratories Ltd. (Caraco), at the companyâ€™s Michigan facilities in Detroit, Farmington Hills, and Wixom. The seizure also includes ingredients held at these same facilities. â€œThe FDA is committed to taking enforcement action against firms that do not manufacture drugs in accordance with our good manufacturing practice requirements,â€ said Janet Woodcock, M.D., director of the FDAâ€™s Center for Drug Evaluation and Research. â€œCompliance with these standards prevents harm to the public.â€
This action follows Caracoâ€™s continued failure to meet the FDAâ€™s current Good Manufacturing Practice (cGMP) requirements, which assure the quality of manufactured drugs. Through this seizure, the FDA seeks to immediately stop the firm from further distributing drugs until there is assurance that the firm complies with good manufacturing requirements.
Since January 2009, Caraco has initiated voluntary recalls of drug products to protect the public from potentially defective medications. The recalls involved manufacturing defects, including oversized tablets and possible formulation error.
The FDA has determined that the seizure of Caraco's drugs may create a shortage of one product, choline magnesium trisalicylate oral tablets, which are commonly used as pain relievers. The FDA recommends in the event of a shortage, that health care providers consider alternative treatments that are safe and effective. Consumers and health care providers who are unable to obtain any of Caracoâ€™s products should contact the FDA Drug Shortage Program by e-mail at email@example.com, or by telephone at 888-463-6332 or 301-796-3400.
The FDAâ€™s most recent inspection of Caraco, completed in May 2009, found unresolved violations of cGMP requirements. Todayâ€™s seizure is intended to lead to major changes at Caracoâ€™s facilities.
If the FDA identifies further significant problems, which pose risks to patient safety with any Caraco drug products on the market, the agency will take appropriate additional regulatory action and immediately notify the public.
"The FDA will continue to take swift, aggressive enforcement action when firms are identified as being in violation of our manufacturing requirements," said Michael Chappell, FDA acting associate commissioner for regulatory affairs.
Seizure of drug products is an effective remedy when there is evidence of continued poor compliance with cGMPs. Following a drug product seizure, companies often agree to a wide range of changes and improvements to their drug manufacturing practices at their facilities.
To view Questions and Answers on Caraco Drugs, Including a List of Effected Drugs:
To view Facts About Current Good Manufacturing Practices:
To view the October 31, 2008 FDA Warning Letter to Caraco Pharmaceutical Laboratories, Ltd: