Anthramycin
Definition of Anthramycin A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium streptomyces refuineus var. thermotolerans. Anthramycin binds covalently to guanine…
10
Wortmannin
Definition of Wortmannin A potent fungal metabolite isolated from Penicillium wortmannin that selectively inhibits phosphatidylinositol 3-kinase and affects the signal…
Pristane
Definition of Pristane A natural or synthetic isoprenoid hydrocarbon (C19) derivative, Pristane is commonly used in research to prime the…
Cyclopamine
Definition of Cyclopamine see: Cyclopamine (2’R,3S,3’R,3’aS,6’S,6aS,6bS,7’aR,11aS,11bR)-1,2,3,3’a,4,4′,5′,6,6′,6a,6b,7,7′,7’a,8,11,11a,11b-Octadecahydro-3′,6′,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2′(3’H)-furo[3,2-b]pyridin]-3-ol 11-Deoxyjervine 3,4′-Dinitroflavone Cyclopamine is from the group Steroid Hormone Other Names for Cyclopamine Cyclopamine…
Carubicin
Definition of Carubicin An anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and inhibits topoisomerase…
Tacrolimus
Definition of Tacrolimus A macrolide isolated from the fungus streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a…
Ixabepilone
Definition of Ixabepilone An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to and stabilizes tubulin…
Clupanodonic Acid
Definition of Clupanodonic Acid see: Clupanodonic Acid 22:5 n-3 All-cis-docosa-7,10,13,16,19-pentaenoic acid Clupanodonic Acid is from the group Docosapentaenoic Acid Omega-3…
Danazol
Definition of Danazol A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of…
Didemnin B
Definition of Didemnin B A cyclic depsipeptide extracted from the caribbean tunicate Trididemnum cyanophorum. Didemnin B activates caspase, thereby inducing…