Definition of Sulfinpyrazone

A phenylbutazone derivative with uricosuric and antithrombotic properties. Sulfinpyrazone competitively inhibits reabsorption of urate at the proximal renal tubule in the kidney. This agent acts on the organic anion transport exchanger, thereby increasing uric acid excretion and decreasing serum uric acid levels resulting in the prevention of urate deposition. Sulfinpyrazone also blocks tubular excretion of various acidic drugs, resulting in increased serum concentration of the drugs. In addition, sulfinpyrazone and its active metabolite inhibit the synthesis of thromboxane A2, by competitively inhibiting the activity of cyclooxygenase, thereby preventing platelet aggregation through restoration of platelet survival time to normal, and decreasing platelet adhesiveness to subendothelial cells.

Sulfinpyrazone is from the group

Uricosuric Agent

Other Names for Sulfinpyrazone

Sulfinpyrazone
3,5-Pyrazolidinedione, 1,2-diphenyl-4-(2-(phenylsulfinyl)ethyl)-
Anturane
Enturen
SULFINPYRAZONE

Source

NCI Thesaurus License

Topics #1 #2-diphenyl-4-(2-(phenylsulfinyl)ethyl)- Anturane Enturen SULFINPYRAZONE #5-Pyrazolidinedione #Sulfinpyrazone 3