Definition of Protein Kinase-A C-Alpha

Expressed as 2 alternative isoforms (sperm-specific isoform 2) by human PRKACA Gene (cAMP Ser/Thr protein kinase Family), protein kinase A C-Alpha is a catalytic subunit of tetrameric inactive cytoplasmic holoenzyme protein kinase A. Homo- or heterodimeric regulatory subunits of inactive PKA holoenzyme are associated with two catalytic subunits. Most cellular effects of cAMP are mediated through PKA. cAMP-induced dissociation of holoenzyme releases a dimer of cAMP-bound regulatory subunits and free monomeric catalytic subunits that serine/threonine phosphorylate many cytoplasmic and nuclear substrates. (NCI)

Protein Kinase-A C-Alpha is from the group

Protein Kinase-A

Other Names for Protein Kinase-A C-Alpha

Protein Kinase A C-Alpha
PKA C-Alpha
PRKACA
cAMP-Dependent Protein Kinase Alpha
cAMP-Dependent Protein Kinase Alpha-Catalytic Subunit

Source

NCI Thesaurus License

Topics #Protein Kinase A C-Alpha PKA C-Alpha PRKACA cAMP-Dependent Protein Kinase Alpha cAMP-Dependent Protein Kinase Alpha-Catalytic Subunit