Definition of Perifosine

An orally active alkyl-phosphocholine compound with potential antineoplastic activity. targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. (NCI04)

Perifosine is from the group

Alkylphosphocholine Compound
Protein Kinase C Inhibitor

Other Names for Perifosine

Perifosine
4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium, Inner Salt
D21266
Octadecyl-(N,N-dimethylpiperidino-4-yl)phosphate
Octadecylphosphopiperidine
PERIFOSINE
perifosine

Source

NCI Thesaurus License

Topics #1-dimethylpiperidinium #Inner Salt D21266 Octadecyl-(N #N-dimethylpiperidino-4-yl)phosphate Octadecylphosphopiperidine PERIFOSINE perifosine #Perifosine 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1