Definition of Myelin Protein Zero-Like-1 Protein

Widely expressed (highest in heart, placenta, kidney, and pancreas) by human MPZL1 Gene (Ig Superfamily), 269-aa 43-kD hyperphosphorylated cell surface membrane glycoprotein myelin protein Zero-Like 1 protein contains an N-terminal signal sequence, an extracellular Ig-like domain with potential N-linked glycosylation sites, a single membrane-spanning segment, and an intracellular pair of consensus immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Specifically binding through its ITIMs to tyrosine phosphatase PTPN11, a positive transducer of growth factor signal transduction, MPZL1 is dephosphorylated by PTPN11, but not by PTPN6, which has a negative role in hematopoietic cell proliferation. Having 45.8% identity with myelin protein Zero, MPZL1 may have a role in cell signaling via c-Src. (NCI)

Myelin Protein Zero-Like-1 Protein is from the group

Immunoprotein

Other Names for Myelin Protein Zero-Like-1 Protein

Myelin Protein Zero-Like 1
MPZL1
PZR
Protein Zero-Related

Source

NCI Thesaurus License

Topics #Myelin Protein Zero-Like 1 MPZL1 PZR Protein Zero-Related