Definition of Mitozolomide

A prodrug of imidazotetrazine alkylating agent with antineoplastic property. Mitozolomide undergoes ring opening upon the nucleophilic attack at C-4 by an activated molecule of water within the major groove of DNA. The resulting bioactive mono-alkyltriazene species are capable of alkylating nucleophilic residues in the immediate vicinity such as N-7 and/or O-6 sites of guanine, thereby causes intra- or inter-stranded DNA cross-links and trigger apoptosis.

Mitozolomide is from the group

Triazene Compound

Other Names for Mitozolomide

Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo-
imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo


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Topics #1-d]-1 #2 #3 #3-(2-chloroethyl)-3 #4-dihydro-4-oxo #4-dihydro-4-oxo- MITOZOLOMIDE imidazo[5 #5-tetrazine-8-carboxamide #Mitozolomide Azolastone Imidazo[5