Definition of MAD MXI1

MAD and MXI1 bZIP proteins belong to a subfamily of MAX-interacting proteins. MAX interacts with MYC via bZIP interaction domains and MAX binding is essential for MYC activity — MYC homodimers are inactive. MAD/MAX and MXI1/MAX heterodimers form a DNA-binding complex similar to MYC/MAX. MAD and MXI1 act as transcriptional repressors and appear to antagonize MYC by competing for MAX, and for dna binding sites, and recruit SIN3 proteins and their associated co-repressors. (from OMIM 600021, 600020, and NCI)

MAD MXI1 is from the group

Retired Concepts

Other Names for MAD MXI1



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Topics #MAD/MXI1