Definition of Lamivudine

A synthetic nucleoside analogue with activity against hepatitis b virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial dna polymerase. (NCI04)

Lamivudine is from the group

Reverse Transcriptase Inhibitor

Other Names for Lamivudine

Lamivudine
3TC
Epivir
LAMIVUDINE
lamivudine

Source

NCI Thesaurus License

Topics #Lamivudine 3TC Epivir LAMIVUDINE lamivudine