Definition of Immunoglobulin Lambda Locus

This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment — the C segment is later joined by splicing at the RNA level. recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)

Immunoglobulin Lambda Locus is from the group

Immunoglobulin Family Gene

Other Names for Immunoglobulin Lambda Locus

Immunoglobulin Lambda Locus
IGL
Immunoglobulin Lambda Gene
Lambda Light Chain Gene

Source

NCI Thesaurus License

Topics #Immunoglobulin Lambda Locus IGL Immunoglobulin Lambda Gene Lambda Light Chain Gene