Definition of Immunoglobulin Heavy Locus

This region represents the germline organization of the immunoglobulin heavy chain locus. The locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a D segment with a J segment — a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)

Immunoglobulin Heavy Locus is from the group

Immunoglobulin Family Gene

Other Names for Immunoglobulin Heavy Locus

Immunoglobulin Heavy Locus
IGH
Immunoglobulin Heavy Chain Gene
Immunoglobulin Heavy Chain Locus
Immunoglobulin Heavy Gene

Source

NCI Thesaurus License

Topics #Immunoglobulin Heavy Locus IGH Immunoglobulin Heavy Chain Gene Immunoglobulin Heavy Chain Locus Immunoglobulin Heavy Gene