Definition of Fulvestrant

A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. in vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04)

Fulvestrant is from the group

Selective Estrogen Receptor Down Regulator

Other Names for Fulvestrant

Fulvestrant
“Faslodex (Fulvestrant, ICI182780)”
7a-[9-[(4,4,5,5,5,-Pentafluoropentyl)sulphinyl]nonyl]-estra-1,3,5(10)-triene-3,17b-diol
FULVESTRANT
Faslodex
Faslodex(ICI 182,780)
ICI 182,780
ICI 182780
ZD9238

Source

NCI Thesaurus License

Topics #-Pentafluoropentyl)sulphinyl]nonyl]-estra-1 #17b-diol FULVESTRANT Faslodex Faslodex(ICI 182 #3 #4 #5 #5(10)-triene-3 #780 ICI 182780 ZD9238 #780) ICI 182 #Fulvestrant "Faslodex (Fulvestrant #ICI182780)" 7a-[9-[(4