Definition of Fostriecin

An anti-tumor antibiotic isolated from the bacterium streptomyces pulveraceus. Fostriecin inhibits topoisomerase II catalytic activity, resulting in protein-associated strand breaks and impaired DNA and rna synthesis in various malignant cell types. This agent also inhibits serine/threonine protein phosphatase type 2A in some tumor cell types, thereby interfering with cellular proliferation and differentiation. (NCI04)

Fostriecin is from the group

Protein Phosphatase Inhibitor
Topoisomerase-II Inhibitor

Other Names for Fostriecin

Fostriecin
2H-pyran-2-one,5,6-dihydro-6-(3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11,-tridecatetraenyl)-,trans
FST
Phosphotrienin

Source

NCI Thesaurus License

Topics #-tridecatetraenyl)- #11 #13-trihydroxy-3-methyl-4-(phosphonooxy)-1 #5 #6 #6-dihydro-6-(3 #7 #9 #Fostriecin 2H-pyran-2-one #trans FST Phosphotrienin