Definition of E-Cadherin

Encoded by human CDH1 Gene (CDH Family), 882-amino acid 97 kD (precursor) invasion suppressor type I membrane protein E-Cadherin is the main homodimeric Ca(2+)-dependent cell-cell adhesion glycoprotein in non-neural epithelia. Structurally similar to immunoglobulins, E-cadherin contains five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail required for internalization. E-Cadherin acts as ligand for integrin Alpha-E/Beta-7. CDH1 defects cause Familial gastric Cancer. CDH1 mutations are correlated with breast, colorectal, thyroid, and ovarian cancer. E-cadherin down regulation often correlates with invasive potential and poor prognosis of human carcinomas — it is likely a main event in cancer proliferation, invasion, and metastasis, due to dysfunction of cell-cell adhesion. (from LocusLink, SWISS-PROT, OMIM, and NCI)

E-Cadherin is from the group

Cadherin

Other Names for E-Cadherin

E-Cadherin
CAM 120/80
CDH1
Cadherin-1
Epithelial Calcium-Dependent Adhesion Protein
Epithelial-Cadherin
Uvomorulin

Source

NCI Thesaurus License

Topics #E-Cadherin CAM 120/80 CDH1 Cadherin-1 Epithelial Calcium-Dependent Adhesion Protein Epithelial-Cadherin Uvomorulin