Definition of Diflunisal

A difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. Diflunisal differs from other salicylates, in that it is not metabolized to salicylic acid, hence it has a longer half-life.

Diflunisal is from the group

Nonsteroidal Antiinflammatory Drug

Other Names for Diflunisal

Diflunisal
(1,1′-Biphenyl)-3-carboxylic Acid, 2′,4′-difluoro-4-hydroxy-
2′,4′-Difluoro-4-hydroxy-(1,1′-biphenyl)-3-carboxylic Acid
Apo-Diflunisal
DIFLUNISAL
Dolobid
Flovacil
Novo-Diflunisal
Nu-Diflunisal

Source

NCI Thesaurus License

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