Definition of Bizelesin

A synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting dna replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. (NCI04)

Bizelesin is from the group

DNA Minor Groove Binding Agent
Miscellaneous Alkylating Agent

Other Names for Bizelesin

Bizelesin
Benzo[1,2-b:4,3-b’]dipyrrol-4-ol, 6, 6′-[carbonylbis(imino- 1H-indole-5, 2-diylcarbonyl)]bis[8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-, [S-(R*,R*)]
U-77779
benzo(1,2-b:4,3-b’)dipyrrol-4-ol,6,6′-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,(S-(R*,R*))
bizelesin

Source

NCI Thesaurus License

Topics #[S-(R* #2-b:4 #2-diylcarbonyl)]bis[8-(chloromethyl)-3 #3-b']dipyrrol-4-ol #6 #6'-[carbonylbis(imino- 1H-indole-5 #7 #8-tetrahydro-1-methyl- #Bizelesin Benzo[1 #R*)) bizelesin #R*)] U-77779 benzo(1