Definition of AML1-ETO Chimeric Protein

In acute myeloid leukemia, the frequent t(8 — 21)(q22 — q22) translocation produces a chimeric AML1/ETO gene. Association of the AML1/ETO product with the NCOR/HDAC complex blocks hematopoietic differentiation. The interaction requires ETO coiled-coil regions and is responsible for abnormal recruitment of NCOR, transcriptional repression, and impaired differentiation of primary hematopoietic precursors. AML1/ETO transcripts are present in a fraction of stem cells, monocytes, marrow B-cells, and in colony-forming cells of erythroid, granulocyte-macrophage, and/or megakaryocyte lineages, but not in T-cells. (from OMIM 133435 and NCI)

AML1-ETO Chimeric Protein is from the group

Fusion Protein

Other Names for AML1-ETO Chimeric Protein

AML-1/ETO
Acute Myeloid Leukemia-1/Eight-Twenty-One Protein

Source

NCI Thesaurus License

Topics #AML-1/ETO Acute Myeloid Leukemia-1/Eight-Twenty-One Protein