Definition of Telomere Maintenance

Telomeres enable cells to distinguish natural chromosome ends from damaged DNA because uncapped telomeres elicit a dna damage response that halts cell proliferation. The protection of human chromosome ends primarily depends on the telomeric protein TRF2 and telomere capping involves the formation of a higher order structure, the telomeric loop or t-loop. Telomeres consist of a tandem array of telomeric DNA repeats bound to specialized telomeric proteins. telomerase activity lengthens terminal regions of eukaryotic telomeric DNA by RNA-templated addition of repeated DNA sequences. Active telomerase forms a structure at the telomere that prevents chromosome ends from being sensed as DNA damage. telomerase is regulated by sequence-specific dna binding proteins that bind telomeric DNA repeats. Through separate domains, these proteins bind additional proteins to assemble a higher-order complex on the telomeric DNA. (from PMID 11850778 and NCI)

Telomere Maintenance is from the group

DNA Maintenance

Other Names for Telomere Maintenance

Telomere Maintenance

Source

NCI Thesaurus License

Topics #Telomere Maintenance