Definition of MLN2704

An immunoconjugate that consists of a humanized monoclonal antibody (MLN591), directed against prostate-specific membrane antigen linked to a maytansinoid (DM1). The monoclonal antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane antigen — MLN274 is then internalized into the tumor cell where the DM1 maytansinoid moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and cell death. (NCI04)

MLN2704 is from the group

Immunoconjugate

Other Names for MLN2704

MLN2704
MLN591DM1

Source

NCI Thesaurus License

Topics #MLN2704 MLN591DM1