Definition of MDM2 Protein

Inhibits p53 trans-activation, cell cycle arrest, and apoptosis. MDM2 binds p53 in the cell cycle at S/G2M phase and targets p53 for proteasome-mediated proteolysis. MDM2 also inhibits Rb protein and binds p14(ARF), ribosomal protein L5, and specifically to RNA. MDM2 gene expression is induced by dna damage and regulated by the Ras-MAP kinase pathway. Some soft tissue sarcomas carry amplified MDM2 and overexpress MDM2 protein. (from SWISS-PROT Q00987, OMIM 164785, and NCI)

MDM2 Protein is from the group

Ligand Binding Protein

Other Names for MDM2 Protein

MDM2 Protein
Double Minute 2 Protein
HDM2
MDM 2 Protein
MDM2
Ubiquitin-Protein Ligase E3 MDM2
p53 Binding Protein
p53-Binding Protein MDM2

Source

NCI Thesaurus License

Topics #MDM2 Protein Double Minute 2 Protein HDM2 MDM 2 Protein MDM2 Ubiquitin-Protein Ligase E3 MDM2 p53 Binding Protein p53-Binding Protein MDM2