Definition of 10-Propargyl-10-Deazaaminopterin

A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, 10-propargyl-10-deazaaminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis.

10-Propargyl-10-Deazaaminopterin is from the group

Folate Antagonist

Other Names for 10-Propargyl-10-Deazaaminopterin

Pralatrexate
10-Propargyl-10-Deazaaminopterin
10-propargyl-10-deazaaminopterin
PDX

Source

NCI Thesaurus License

Topics #Pralatrexate 10-Propargyl-10-Deazaaminopterin 10-propargyl-10-deazaaminopterin PDX